Alginate/Chitosan Nanoparticles for Adsorption and Controlled Release of Pemetrexed

Pemetrexed (PEM) is used for treatment of non-small cell lung cancer. However, PEM has disadvantages like fast elimination, low bioavailability, poor tumor selectivity, and penetration. Thus, there a need using pemetrexed delivery system to increase the anticancer effect drug in cancer cells minimize its side effects. The purpose this study development alginate/chitosan nanoparticles (ACNP) that have biodegradable non-toxic structure effective therapy. In present study, ACNP were prepared ionic gelation method, was loaded via adsorption method. Drug efficiency calculated be 57.80% characterization studies performed. vitro release tests carried out at pH levels 5.5 7.4 with pemetrexed-loaded (PACNP) free pemetrexed, both results subsequently compared. Up 11% yield observed 5.5, reached up 7% 25 hours. This nanoparticle could investigated vivo further controlled pemetrexed.